The noncoding regions of human genome are transcribed into thousands of RNA molecules. The first microRNA, lin-4 was reported in 1993, but it came to a research spot until let-7 was confirmed in 2000. Now, vital roles noncoding RNAs in the development of cancer have been recognized . Noncoding RNAs, such as miRNAs, tRNA-derived fragments (tRF), circRNAs and long noncoding RNAs (lncRNAs) as key players in metabolic diseases, especially tumorigenesis.
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